Cisplatin sensitivity
WebMar 15, 2003 · Cisplatin-resistance cell lines CP70, C30, and C200 were produced by intermittent, incremental exposure of the sensitive parental A2780 cell line to various concentrations of cisplatin. OVCAR-4 and OVCAR-10 cell lines were developed from patients who were clinically refractory to platinum-based chemotherapy (16, 17). WebFor the first time, our study implies that d-borneol enhanced cisplatin sensitivity by inducing ferroptosis, promoting autophagy and inhibiting EMT progression, thereby …
Cisplatin sensitivity
Did you know?
WebMay 1, 2003 · In such an instance, cancer cells may escape the apoptotic consequence of cisplatin exposure but still sustain major genotoxic insults. Considering that apoptosis may be impaired, using... WebAug 24, 2024 · Cisplatin (CDDP) remains one of the most widely used first-line drugs in the therapy of NSCLC, based on the clinical data that the poor outcomes of untreated …
WebJun 24, 2011 · ICL-based chemotherapy is one of the most widely used forms of cancer treatment, particularly in the treatment of leukaemias. Fanconi anaemia (FA) is a disorder that results in sensitivity to... WebWorldwide, the number of cancer-related deaths continues to increase due to the ability of cancer cells to become chemotherapy-resistant and metastasize. For women with ovarian cancer, a staggering 70% will become resistant to the front-line therapy, cisplatin. Although many mechanisms of cisplatin resistance have been proposed, the key mechanisms of …
WebWorldwide, the number of cancer-related deaths continues to increase due to the ability of cancer cells to become chemotherapy-resistant and metastasize. For women with … WebAug 1, 2024 · Excellent sensitivity of TC tumors to cisplatin treatment has made TC a highly curable disease. Two features of TC tumors contribute to cisplatin sensitivity, …
WebJul 14, 2024 · Mechanismly, propofol enhances cisplatin sensitivity of NSCLC through miR-486-5p/RAP1-NF-κB axis. The finding provides a deeper understanding about the …
Web2 days ago · Blockade of neddylation increases cisplatin sensitivity of testicular germ cell tumors. In turn, inhibition of the neddylation cascade leads to an accumulation of suppressor proteins and ... how far is syracuse from ithaca nyWebMar 8, 2024 · XPV fibroblasts are sensitive to UV light and cisplatin but are corrected by transfection of POLHcDNA [1,13]. In this context, it is reasonable to postulate that human germline POLHvariants can alter the TLS activity and thus modify the susceptibility to toxic effects of UV and cisplatin in genetically affected individuals. highchair one or two wordsWebJul 22, 2024 · Figure 1 Olaparib and cisplatin (CDDP) in vitro sensitivities are not influenced by the BRCA1 status of TNBC cells. (A) MTT assays of MDA-MB-468, SUM1315, MDA-MB-231 and HCC1937 cells. Data are mean ± S.D. of three independent experiments. (B) Isobologram analysis of the combination of olaparib and CDDP in constant 1:1 ratio. high chair offersWebDec 9, 2024 · By analysing RNA-seq data in OSCC cells treated with vitamin D and cisplatin, we found that lipocalin 2 (LCN2) was an important modulator of cisplatin … how far is t2 from t3 manchester airportWebFactors contributing to the observed cisplatin sensitivity include defective DNA damage repair and a hypersensitive apoptotic response to DNA damage. Nonetheless, around 10 … high chair one word or twoWebApr 9, 2024 · This unique side effect has been linked to a drug called oxaliplatin, which is used to treat several types of cancer, including … how far is syracuse ny to columbus ohWebJul 26, 2024 · Background: Cisplatin (CDDP) is commonly used to treat non-small cell lung cancer (NSCLC), but the appearance of drug resistance greatly hinders its … high chair online