The v-atpase: small cargo large effects

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WebMar 14, 2012 · VHA-c has a major role in transporting ions. In addition, it is involved in many stress responses such as salt stress, low temperature, heat and so on. The enhancement in the expression of V-H + -ATPase subunits has been demonstrated under salt- and abscisic acid (ABA)-induced stress (Kasai et al. 1994 ). WebThe v-ATPase is homologous to the F-type mitochondrial ATP synthase and these two enzyme complexes are thought to share genetic ancestors (Nelson, 1992). The v-ATPase uses energy from ATP hydrolysis to actively transport H + ions into the lysosome, thereby making the lumen more acidic. At least 13 different protein subunits form the complete v ...

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WebApr 20, 2012 · They found that removing the V 1 section of the V-ATPase using SCN − completely inhibited proton transport activity of the V-ATPase but did not affect the fusion reactions. By contrast, adding DCCD, an inhibitor that bound to the V 0 subunit Vma3, blocked vacuole fusion. WebMay 1, 2024 · cellular processes in all eukaryotes. Difficulty in obtaining preparations of purified V-ATPase from plants in sufficient quantities for structural analysis has hindered determining the 3D structure of the plant V-ATPase. We used the Legionella pneumophila effector SidK to affinity-purify the endogenous V-ATPase from lemon fruit. scott county public defenders office

The V-ATPase: small cargo, large effects

WebCharlotte, North Carolina WebSep 10, 2014 · Two types of proton pumps, the V-ATPase and the vacuolar proton pumping pyrophosphatase (V-PPase), use chemical energy of ATP or pyrophosphate to pump … WebDec 1, 2010 · The V-ATPase: small cargo, large effects. The V-ATPase: small cargo, large effects. pre packed toiletry kit

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WebSchumacher, K., & Krebs, M. (2010). The V-ATPase: small cargo, large effects. Current Opinion in Plant Biology, 13 (6), 724–730. doi:10.1016/j.pbi.2010.07.003 … WebThe V-ATPase: small cargo, large effects. About 30 years ago seminal reports of anion-sensitive proton-pumping activity associated with microsomal membranes initiated … scott county public defender officeWebWe also find that actin is required for sufficient entry of IFT material into flagella during assembly. These same effects are recapitulated with a myosin inhibitor, suggesting that actin may act via myosin in a pathway by which flagellar assembly is regulated by flagellar length. Many UC-authored scholarly publications are freely available on ... pre packed sweets

"WebNov 1, 2014 · The V-ATPase: small cargo, large effects Curr. Opin. Plant Biol. (2010) K. Miwa Homeostasis of the structurally important micronutrients, B and Si Curr. Opin. Plant Biol. (2009) View more references Cited by (190) Foxtail millet MYB-like transcription factor SiMYB16 confers salt tolerance in transgenic rice by regulating phenylpropane pathway " - The v-atpase: small cargo large effects

The v-atpase: small cargo large effects

The coordination of V-ATPase and ATG16L1 is part of a …

WebDec 1, 2010 · The overall structure and mechanism of action of the V- ATPase is supposed to be similar to that of the well-characterized F-type ATP synthase (F-ATPase), but time will tell whether V-ATpase shares an identical mechanism ofaction with F-AT Pase or its mode of operation is unique. 56 PDF WebDec 23, 2012 · Strikingly, knocking down V-ATPase caused the cells to accumulate large and irregular CCPs with average neck diameters of 220 nm (compared with 97 nm in control cells), whereas constricted pits ...

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WebDec 24, 2014 · Like the mitochondrial F-ATPase, the V-ATPase is shaped like a mushroom . There are two subcomplexes: V 1 and V 0. V 1, the “cap,” comprises the sites of ATP hydrolysis; V 1 sits atop the V 0 “stalk,” which conducts H + ions. V 0 consists of six small hydrophobic subunits (proteolipids) and a large subunit, V100. WebThe V-ATPase has a dual role in membrane transport and vesicle trafficking. The V-ATPase in the TGN/EE is essential. Endocytic and secretory trafficking require V-ATPase activity. …

Weba late endosome or lysosome to degrade its cargo. The opposing effects of two lysosomal inhibitors, chloroquine (CQ) and bafilomycin A 1 (BafA1), ... V-ATPase inhibitors impairs LC3A conjugation to the phago-some, which indicates the necessity of ROS and the V-ATPase in this process. Meanwhile, the researchers noticed that the WebMay 25, 2024 · Yeast vacuoles are acidified by the V-ATPase, a protein complex comprised of the membrane embedded VO complex and the soluble cytoplasmic V1 complex. The assembly of the V1-VO holoenzyme is required for the transfer of H+ into the vacuole lumen for acidification. The assembly of the V1-VO holoenzyme is stabilized by the lipid …

WebSep 1, 2011 · Our recent iTRAQ analysis revealed that the levels of V-ATPase subunits A, C and E1 were significantly decreased in the presence of excess zinc in WT plants. 9 … WebThe V-ATPase has a dual role in membrane transport and vesicle trafficking. The V-ATPase in the TGN/EE is essential. Endocytic and secretory trafficking require V-ATPase activity. …

WebThe V-ATPase: small cargo, large effects. 来自 Elsevier 喜欢 0 阅读量： 104 作者： Karin Schumacher ， Melanie Krebs 摘要： About 30 years ago seminal reports of anion-sensitive proton-pumping activity associated with microsomal membranes initiated research on the plant vacuolar-type H +-ATPase (V-ATPase, VHA).

WebOct 25, 2024 · The main functions of V-ATPase are to transport protons to vacuoles by ATP hydrolysis and to generate pH and potential energy gradients inside and outside vacuoles … scott county public health mnWebJun 22, 2016 · The V-ATPases are large, multisubunit complexes organized into a peripheral V 1 domain that carries out ATP hydrolysis and an integral V 0 domain responsible for proton transport ( Figure 1; see Ref. 232 for a … prepacked smoothie sent to homesWebAug 26, 2010 · This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy. pre packed smoothiesWebThe large selection of styles and sizes includes small cargo trailers that are ideal for carrying tools and equipment around the yard or farm. You will also see cargo trailers that … scott county public library scottsburg inWebJan 1, 2024 · V-ATPases are ATP-driven proton pumps present in both intracellular and cell surface membranes of eukaryotes that function in many normal and disease processes. V … scott county public library kyWebBafilomycin is a specific inhibitor of V-ATPase. To characterize the roll of the V-ATPase in viral replication we generated a Bafilomycin A1(BAF) resistant mutant of Sindbis virus (BRSV). scott county public records searchWebMay 25, 2024 · Inhibition of the v-ATPase can be achieved by targeting different subunits in both the V o and V 1 domains, acting to decrease proton transport into the lysosome and … scott county public health jobs